Alzheimer’s Disease: A Systematic Review of Novel Therapies and Vaccines

Authors

  • Maham Kazmi University of California, Los Angeles
  • Guneet Grewal Santa Clara University
  • Alicia Mathew Case Western Reserve University
  • Jocelyn Nee University of California, San Diego

DOI:

https://doi.org/10.52243/bptjm.v6i1.76

Keywords:

Alzheimer's Disease, Dementia, Immunotherapy, Biomarker, Vaccine

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder and the fifth leading cause of death in the United States as of 2021. Current FDA-approved therapies, including cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and memantine, provide symptomatic relief but do not modify disease progression. The anti-amyloid monoclonal antibodies, lecanemab and donanemab, modestly slow cognitive and functional decline in early-stage AD. This review provides a comprehensive overview of the mechanisms underlying AD and research efforts aimed at understanding and treating the disease. Additionally, this paper explores ongoing clinical trials investigating novel treatments such as immunotherapies and small-molecular inhibitors targeting AD biomarkers. Regenerative medicine approaches, including gene and stem cell therapies, show promise in these trials. By understanding current research and future potential for these trials, this review aims to explore strategies for managing and potentially curing AD.

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Author Biographies

Maham Kazmi, University of California, Los Angeles

Maham Kazmi is a 4th-year student at the University of California, Los Angeles, and she is studying molecular, cellular, & developmental biology. Maham is proud of her ability to balance several roles such as UMMA Healthfair Coordinator, editor-in-chief for a school magazine, and a part-time job as an optometric assistant.

Guneet Grewal, Santa Clara University

Guneet Grewal is a senior at Santa Clara University studying bioengineering. She is continuing her Berkeley Pharma Tech internship from the summer of 2024, and she is excited to complete her second research paper. Previously, Guneet and her team wrote a review paper on adolescent brain health intervention strategies. In five years, she hopes to be working in the biotech industry and making a meaningful impact on people's lives. 

Jocelyn Nee, University of California, San Diego

Jocelyn Nee is a 2nd year at the University of California, San Diego, and she is studying biology. She is proud of a recent achievement: finishing her first year of college. In five years, she plans to either be in grad school or to have a career that brings her happiness and fulfillment. 

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Published

2026-01-06

How to Cite

Kazmi, M., Grewal, G., Mathew, A., & Nee, J. (2026). Alzheimer’s Disease: A Systematic Review of Novel Therapies and Vaccines. Berkeley Pharma Tech Journal of Medicine, 6(1), 80–100. https://doi.org/10.52243/bptjm.v6i1.76

Issue

Vol. 6 No. 1 (2026)

Section

Scientific Review Papers

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.