Advancing Wound Healing: Innovative Pathway Strategies for Enhanced Recovery

Abstract

As the largest organ of the body, it is crucial that the skin, and all it protects, remain healthy and functioning. However, burn injuries may result as a serious threat to the skin, possibly forming greater health issues depending on the severity of the issue. Burn wound injury is characterized as damage to the skin or other organic tissue originating from sources such as heat, friction, radiation, radioactivity, electricity, and/or chemical contact. Different degrees of burn wounds make it increasingly more difficult to treat the more severe the wound is. For this reason, it is crucial to study how skin can not only heal itself via its own equipped healing related pathways, but also what treatments exist outside of the ongoing biochemical mechanisms in order to accelerate healing and repair the body’s greatest defense. More standard forms of treatment that currently exist adopt a more holistic approach, treating at the surface level, while treatments targeting the molecular level are less well studied. This review paper assesses several novel therapeutic alternatives including, but not limiting to, targeting lncRNA XIST, IL-33, and miR-19b through analyzing the molecular pathways in which wound healing is performed.